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KMID : 0061119810090000105
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Bulletin of the Clinical Research Institute
1981 Volume.9 No. 0 p.105 ~ p.105
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Effect of Alpha-Adrenergic Blockade on the Lung and Hypothalamic Lesions in the Experimental Neurogenic Pulmonary Edema
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Kang, Joon-Ki
Park, Min-Woo/Lee, Choon-Jang/Huh, Choon-Woong/Song, Jin-Un
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Abstract
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An experimental neurogenic pulmonary edema model in cats is described in which we have attempted to produce a neurogenically mediated homo dynamic data, lung weight, and histopathological changes of lung and hypothalamus were studied in groups of phentolamine treated animals, . whey intracranal pressure was raised to 200 or 300 mmH2 O for 2 hours.
It might be inferred from these results that the lungs are directly affected´ by intense sympathetic discharge evoked by release phenomenon from the sympatho-inhibitory area of the hypothalamus and pulmonary edema was effectively eliminated by alpha-adrenergic blockade.
These results suggest that the lungs are directly affected by the intense sympathetic discharge evoked by release phenomenon from the, sympathoinhibitory area of the hypothalamus and pulmonary edema was effectively eliminated by alpha-adrenergic blockade (phentolamine).
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